反应条件
1: t-BuOK / ethanol / 3 h / Heating 2: 81 percent / H2O2 / H2O / 20 h / 45 °C 3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 5: 70 percent / KOH / methanol / 7 h / -30 °C 6: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 116, # 9 p. 485 - 490
