cesium fluoride in N,N-dimethyl-formamide 12 h; Ambient temperature;

1.1: AlCl3, aluminium chloride / dichloromethane / 0.25 h / 20 °C / |Inert atmosphere; |Cooling with acetone-dry ice 1.2: 20 °C / |Inert atmosphere 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C / |Inert atmosphere 3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 4 h / 80 °C / |Inert atmosphere 4.1: potassium fluoride; hydrogen bromide; acetic acid / N,N-dimethyl-formamide / 1.5 h / 0 °C / |Inert atmosphere View Scheme