(4R,5S,6S,7R)-5,6-二羟基-1,3,4,7-四(苯基甲基)-1,3-二氮杂环庚-2-酮合成路线 （共 14 条）
反应条件
1: MgSO4 / CH2Cl2 / 4 h / Ambient temperature
2: 74 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
3: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature
4: NaBH4 / ethanol / 18 h / 60 °C
5: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
6: 79 percent / HCl / dioxane / 3 h / Ambient temperature
View Scheme
参考文献
Dondoni, Alessandro; Perrone, Daniela; Rinaldi, Marilisa
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9252 - 9264
反应条件
1: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
2: 79 percent / HCl / dioxane / 3 h / Ambient temperature
View Scheme
参考文献
Dondoni, Alessandro; Perrone, Daniela; Rinaldi, Marilisa
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9252 - 9264
反应条件
1: 74 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
2: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature
3: NaBH4 / ethanol / 18 h / 60 °C
4: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
5: 79 percent / HCl / dioxane / 3 h / Ambient temperature
View Scheme
参考文献
Dondoni, Alessandro; Perrone, Daniela; Rinaldi, Marilisa
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9252 - 9264
反应条件
1: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature
2: NaBH4 / ethanol / 18 h / 60 °C
3: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
4: 79 percent / HCl / dioxane / 3 h / Ambient temperature
View Scheme
参考文献
Dondoni, Alessandro; Perrone, Daniela; Rinaldi, Marilisa
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9252 - 9264
