1H-苯并三唑-1-甲腈合成路线 （共 19 条）
反应条件
1: 1,2,3-Benzotriazole With sodium methylate in methanol Metallation; 2: bromocyane in chloroform T=25°C; Addition;
参考文献
Purygin, P. P.; Pan'kov, S. V.; Belyakova, N. A.
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 3 p. 474 - 474
Zhurnal Organicheskoi Khimii, 1999 , vol. 35, # 3 p. 496 - 496
反应条件
in tetrahydrofuran T=20°C; Substitution; 1 h;
参考文献
Katritzky, Alan R.; Brzezinski, Jacek Z.; Lam, Jamshed N.
Revue Roumaine de Chimie, 1991 , vol. 36, # 4-7 p. 573 - 580
反应条件
in acetonitrile 24 h; Ambient temperature;
参考文献
Hughes, Terry V.; Hammond, Stephen D.; Cava, Michael P.
Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 401 - 402
反应条件
1: 97 percent / NaOCl / acetic acid; H2O / 2 h 2: 70 percent / acetonitrile / 24 h / Ambient temperature View Scheme
参考文献
Sheludyakov, V. D.; Sheludyakova, S. V.; Kuznetsova, M. G.; Silkina, N. N.; Mironov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1980 , vol. 50, # 4 p. 875 - 881,705 - 711
反应条件
sodium ethanolate 1) methanol, 2) CHCl3, RT, 24 h;
参考文献
Purygin, P. P.; Pan'kov, S. V.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 6 p. 865 - 867
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 6 p. 934 - 936
参考文献
Sheludyakov, V. D.; Sheludyakova, S. V.; Kuznetsova, M. G.; Silkina, N. N.; Mironov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1980 , vol. 50, # 4 p. 875 - 881,705 - 711
反应条件
in N,N-dimethyl-formamide T=35 - 40°C; Substitution; 6 h;
参考文献
Katritzky, Alan R.; Brzezinski, Jacek Z.; Lam, Jamshed N.
Revue Roumaine de Chimie, 1991 , vol. 36, # 4-7 p. 573 - 580
反应条件
n-butyllithium 1.) Et2O, 0 deg C, 30 min, 2.) Et2O, -78 deg C; Yield givenMultistep reaction;
参考文献
Hughes, Terry V.; Cava, Michael P.
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 313 - 315
反应条件
ammonium chloride in tetrahydrofuran; water; toluene
参考文献
H. Lundbeck A/S
Patent: US2002/128497 A1, 2002 ;
反应条件
n-butyllithium 1.) THF, 0 deg C, 30 min, 2.) THF, -78 deg C; Yield givenMultistep reaction;
参考文献
Hughes, Terry V.; Cava, Michael P.
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 313 - 315
