1: 50 percent / H2SO4; AcOH / 90 °C 2: 60 percent / NaH / dimethylformamide / 80 °C View Scheme

sulfuric acid; acetic acid T=100°C; 1 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br />&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '123183', constants.ctx, '0')">5,5'-dimethyl-2,2'-bipyridine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1446024', constants.ctx, '0')">methanesulfonic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '15732764', constants.ctx, '0')">palladium (II) trifluoroacetate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102448', constants.ctx, '0')">2-methyl tetrahydrofuran</a> <br />T=80&deg;C;&nbsp;36&nbsp;h;&nbsp;&nbsp;Schlenk technique;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 89 percent / sodium hydroxide / H₂O / 5 - 60 &deg;C<br />2: 99 percent / phosphorus oxychloride; tin(IV) chloride / CH₂Cl₂ / 12 h / Heating<br />3: 89 percent / hydochloric acid; AcOH / Heating<br /> <br /> &nbsp;