5-羟基甲基-2-甲基呋喃-3-羧酸甲酯合成路线 （共 7 条）
反应条件
1: With sodium tetrahydroborate in methanol; dichloromethane T=0°C; 0.833333 h; 2: With water; sodium hydrogencarbonate in methanol; dichloromethane
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 127 ;
WO 2010/020556 A1
反应条件
1.1: POCl3 / 0 - 40 °C 1.2: 90 percent / aq. NaOH 2.1: 88 percent / NaBH4 / methanol View Scheme
参考文献
Stephen; Hashmi; Woelfle; Ata, Filiz; Hamzic, Melissa; Salathe, Ralph; Frey, Wolfgang
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 16-17 p. 2501 - 2508
反应条件
in N,N-dimethyl-formamide T=90°C; 8 h;
参考文献
Toro, Andras; Deslongchamps, Pierre
Synthetic Communications, 1999 , vol. 29, # 13 p. 2317 - 2321
反应条件
in ethanol 192 h; Heating;
参考文献
Fernandez, M. Valpuesta; Herrera, F. J. Lopez; Cobos, T. Lupion
Heterocycles, 1986 , vol. 24, # 3 p. 679 - 686
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane T=0 - 20°C;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 127-128 ;
WO 2010/020556 A1
反应条件
chromium(VI) oxide in pyridine; water
参考文献
Pevzner
Russian Journal of General Chemistry, 2001 , vol. 71, # 7 p. 1045 - 1049
反应条件
1: 74 percent / chromic anhydride / H2O; pyridine
2: 47 percent / triethyl orthoformate; p-toluenesulfonic acid / CHCl3 / 10 h / Heating
View Scheme
参考文献
Pevzner
Russian Journal of General Chemistry, 2001 , vol. 71, # 7 p. 1045 - 1049
