(2R,3S)-3-(苯甲酰基氨基)-2-羟基苯丙酸乙酯合成路线 （共 43 条）
反应条件
1: 40 percent / calcium alginate; citrate-phosphate buffer; aq. ammonia / glucose; Saccharomyces cerevisiae / ethanol / 24 h / 30 °C / pH 4.0 2: 86 percent / CaCl2; potassium carbonate / ethanol / 9.5 h 3: 98 percent / BF3*Et2O / 4 h / 20 °C 4: 98 percent / HCl / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 18 p. 3099 - 3106
反应条件
1: 95 percent / CH2Cl2; pyridine / 6 h / 20 °C 2: 90 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 2585.74 Torr View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 3 p. 283 - 286
反应条件
1: 96 percent / SOCl2 / pyridine / 5 h / 0 °C 2: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C 3: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C 4: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C 5: 95 percent / CH2Cl2; pyridine / 6 h / 20 °C 6: 90 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 2585.74 Torr View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 3 p. 283 - 286
反应条件
1: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C 2: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C 3: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C 4: 95 percent / CH2Cl2; pyridine / 6 h / 20 °C 5: 90 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 2585.74 Torr View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 3 p. 283 - 286
反应条件
1: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C 2: 95 percent / CH2Cl2; pyridine / 6 h / 20 °C 3: 90 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 2585.74 Torr View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 3 p. 283 - 286
反应条件
1: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C 2: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C 3: 95 percent / CH2Cl2; pyridine / 6 h / 20 °C 4: 90 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 2585.74 Torr View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 3 p. 283 - 286
反应条件
1: 96 percent / Et3N / CH2Cl2 / 0 °C 2: H2 / Pd/C 3: 1.) diethyl azodicarboxylate, PPh3, 2.) 1N aq. NaOH / 2.) MeOH, 2 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 34, # 6 p. 471 - 473
反应条件
1: 1.) NaN3 / 1.) acetone, H2O, 4 h, 2.) H3O+ 2: 96 percent / Et3N / CH2Cl2 / 0 °C 3: H2 / Pd/C 4: 1.) diethyl azodicarboxylate, PPh3, 2.) 1N aq. NaOH / 2.) MeOH, 2 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 34, # 6 p. 471 - 473
反应条件
1: 55 percent / BF3*OEt2 / 3 h 2: 85 percent / aq. HCl / ethanol / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 23 p. 9654 - 9657
反应条件
1: 99 percent / K2CO3 / dimethylformamide; H2O / 5 h / 20 °C 2: 55 percent / BF3*OEt2 / 3 h 3: 85 percent / aq. HCl / ethanol / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 23 p. 9654 - 9657
