(2R,3S)-3-(苯甲酰基氨基)-2-羟基苯丙酸乙酯合成路线 （共 43 条）
反应条件
1: 70 percent / 1N aq. KOH / 1 h 2: 63 percent / 4-dimethylaminopyridine / tetrahydrofuran / 3.5 h / Heating 3: 95 percent / NaHCO3 / ethanol / 0.5 h / Heating 4: 65 percent / hansenula polymorpha SC 13865 cells / 48 h / 28 °C / K-phosphate buffer (pH 6.0), glucose View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 9 p. 2069 - 2084
反应条件
1: 70 percent / 1N aq. KOH / 1 h 2: 63 percent / 4-dimethylaminopyridine / tetrahydrofuran / 3.5 h / Heating 3: 95 percent / NaHCO3 / ethanol / 0.5 h / Heating 4: 65 percent / hansenula polymorpha SC 13865 cells / 48 h / 28 °C / K-phosphate buffer (pH 6.0), glucose View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 9 p. 2069 - 2084
反应条件
1: 63 percent / 4-dimethylaminopyridine / tetrahydrofuran / 3.5 h / Heating 2: 95 percent / NaHCO3 / ethanol / 0.5 h / Heating 3: 65 percent / hansenula polymorpha SC 13865 cells / 48 h / 28 °C / K-phosphate buffer (pH 6.0), glucose View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 9 p. 2069 - 2084
反应条件
1: 95 percent / NaHCO3 / ethanol / 0.5 h / Heating 2: 65 percent / hansenula polymorpha SC 13865 cells / 48 h / 28 °C / K-phosphate buffer (pH 6.0), glucose View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 9 p. 2069 - 2084
反应条件
1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 2: ethanol; potassium carbonate / 20 °C 3: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 4: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 32 p. 7304 - 7307
反应条件
1: ethanol; potassium carbonate / 20 °C 2: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 3: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 32 p. 7304 - 7307
反应条件
1.1: sodium hydride / toluene / Reflux 2.1: sulfuryl dichloride / dichloromethane / 0 °C 3.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C 4.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 4.2: 20 - 40 °C / Inert atmosphere 5.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 6.1: ethanol; potassium carbonate / 20 °C 7.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 8.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 32 p. 7304 - 7307
反应条件
1.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 1.2: 20 - 40 °C / Inert atmosphere 2.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 3.1: ethanol; potassium carbonate / 20 °C 4.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 5.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 32 p. 7304 - 7307
反应条件
1: 86 percent / CaCl2; potassium carbonate / ethanol / 9.5 h 2: 98 percent / BF3*Et2O / 4 h / 20 °C 3: 98 percent / HCl / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 18 p. 3099 - 3106
反应条件
1: H2 / Pd/C 2: 1.) diethyl azodicarboxylate, PPh3, 2.) 1N aq. NaOH / 2.) MeOH, 2 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 34, # 6 p. 471 - 473
