4-氨基-2-(三氟甲基)苯酚合成路线 （共 6 条）
反应条件
hydrogen; 5 palladium over charcoal in methanol 4 h;
参考文献
SCHERING CORPORATION
Patent: WO2007/97937 A1, 2007 ;
Location in patent: Page/Page column 175 ;
WO 2007/097937 A1
反应条件
water; ammonium chloride; zinc in methanol 1 h;
参考文献
Udagawa, Chikako; Fukuyoshi, Shuichi; Morimoto, Shotaro; Tanimoto, Yoshifumi; Nakagaki, Ryoichi
Journal of Photochemistry and Photobiology A: Chemistry, 2011 , vol. 226, # 1 p. 57 - 63
反应条件
1: Py*HCl / 210 °C 2: H2 / Pd-C View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
WO 2012/100734 A1
反应条件
1.1: sulfuric acid; sodium nitrite / 1 h 1.2: 65 h / 100 °C / Cooling with ice 1.3: 20 °C 2.1: water; ammonium chloride; zinc / methanol / 1 h View Scheme
参考文献
Udagawa, Chikako; Fukuyoshi, Shuichi; Morimoto, Shotaro; Tanimoto, Yoshifumi; Nakagaki, Ryoichi
Journal of Photochemistry and Photobiology A: Chemistry, 2011 , vol. 226, # 1 p. 57 - 63
反应条件
1: (i) aq. HCl, NaNO2, (ii) /BRN= 635743/, CuCl
2: liq. NH3
View Scheme
参考文献
Filler,R. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 4660 - 4662
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetonitrile
T=0°C; 0.5 h;
2: With copper(l) chloride in water; acetonitrile
T=100°C; 6 h;
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
Location in patent: Page/Page column 28-29 ;
WO 2012/100734 A1
