1: With boron trifluoride diethyl etherate in dichloromethane T=0 - 25°C; 2: With sodium hydroxide in dichloromethane; water pH=12 - 14;

1.1: isopropyl alcohol / 2 h / 0 - 20 °C 2.1: toluene-4-sulfonic acid / isopropyl alcohol / 3.5 h / |Reflux 2.2: 3 h / |Reflux View Scheme

1: 3-hydroxy-3-acetoxymercaptomethylquiniclidine thiolacetate With toluene-4-sulfonic acid in isopropyl alcohol 3.5 h; Reflux; 2: 1,1-dimethoxyethane 3 h; Reflux; 3: With hydrogenchloride