4-溴-5-氟-1,2-亚苯基二胺合成路线 （共 6 条）
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 134 ;
WO 2013/026914 A1
反应条件
iron; ammonium chloride in tetrahydrofuran; ethanol; water
T=95°C; 4 h;
参考文献
ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;
Location in patent: Page/Page column 155 ;
反应条件
sodium hydrogencarbonate in ethanol; ethyl acetate
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
1.1: 0.5 h / 0 °C
1.2: 0 - 25 °C
2.1: potassium carbonate / methanol / 0.5 h
3.1: ammonium chloride; iron / ethanol; water; tetrahydrofuran / 4 h / 95 °C
View Scheme
参考文献
ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;
反应条件
1: potassium carbonate / methanol / 0.5 h
2: ammonium chloride; iron / ethanol; water; tetrahydrofuran / 4 h / 95 °C
View Scheme
参考文献
ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;
反应条件
1: acetic acid; N-bromosuccinmide / 1.5 h / |Reflux
2: tin(ll) chloride / ethanol / 14 h / |Reflux
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
