3-二氟甲氧基-4-甲氧基苯甲醛合成路线 （共 5 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20 - 80°C; 18 h;
参考文献
GLENMARK PHARMACEUTICALS LIMITED
Patent: WO2004/22536 A1, 2004 ;
Location in patent: Page 37-38 ;
WO 2004/022536 A1
反应条件
caesium carbonate in N-methyl-acetamide
参考文献
SmithKline Beecham Corporation
Patent: US5449686 A1, 1995 ;
反应条件
potassium carbonate; N,N-dimethyl-formamide T=20 - 60°C; Inert atmosphere;
参考文献
Liu, Haiyan; Li, Gaoping; Wang, Junbo; Liu, Jingwen
Patent: US2011/9628 A1, 2011 ;
Location in patent: Page/Page column 44-45 ;
US 20110009628 A1
反应条件
1: With potassium carbonate in water; N,N-dimethyl-formamide T=20 - 100°C; 20 h; Inert atmosphere; 2: With hydrogenchloride in water; N,N-dimethyl-formamide 3 h;
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; TRACHSEL, Daniel; WILLIAMS, Jodi T.
Patent: WO2010/44054 A1, 2010 ;
Location in patent: Page/Page column 108-109 ;
WO 2010/044054 A1
反应条件
in 1,4-dioxane; 1-chloro-1,1-difluoro-methane
参考文献
Byk Gulden Lomberg Chemische Fabrik GmbH
Patent: US6191138 B1, 2001 ;
