1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮合成路线 （共 24 条）
反应条件
aluminium trichloride T=160°C; 2 h;
参考文献
Moser; Sallmann; Wiesenberg
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2358 - 2368
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C; Acylation; 2 h;
参考文献
Bandarage; Chen; Fang; Garvey; Glavin; Janero; Letts; Mercer; Saha; Schroeder; Shumway; Tam
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 4005 - 4016
反应条件
1: With hydrogenchloride; water 0.166667 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in tetrahydrofuran 3 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/16118 A1, 2009 ;
Location in patent: Page/Page column 40-41 ;
反应条件
zinc in acetic acid 4 h; Heating;
参考文献
Tamura; Uenishi; Choi; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1995 - 1997
反应条件
1: benzene / 6 h / Heating 2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 4: 97 percent / Zn / acetic acid / 4 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 5 p. 1995 - 1997
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 0.5 h;
参考文献
Chung, Man Chin; Dos Santos, Jean Leandro; Oliveira, Ednir Vizioli; Blau, Lorena; Renato Farina Menegon; Peccinini, Rosangela Goncalves
Molecules, 2009 , vol. 14, # 9 p. 3187 - 3197
反应条件
toluene-4-sulfonic acid in ethanol Cyclization;
参考文献
Khalaj; Amanlou; Jorjani
Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 4 p. 201 - 203
反应条件
toluene-4-sulfonic acid in ethanol Cyclization;
参考文献
Khalaj; Amanlou; Jorjani
Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 4 p. 201 - 203
反应条件
1: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 2: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 3: 97 percent / Zn / acetic acid / 4 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 5 p. 1995 - 1997
反应条件
1: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 2: 97 percent / Zn / acetic acid / 4 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 5 p. 1995 - 1997
