1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮合成路线 （共 24 条）
反应条件
1: 77.3 percent / POCl3/DMF / CHCl3 / 6 h 2: 73.5 percent / 1N aq. NaOH / ethanol / 2.5 h / Heating 3: 95 percent / 10percent aq. HCl View Scheme
参考文献
Predvoditeleva, G. S.; Kartseva, T. V.; Oleshko, O. N.; Shvedov, V. I.; Syubaev, R. D.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 4 p. 275 - 278
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 4 p. 441 - 445
反应条件
1: 77.3 percent / POCl3/DMF / CHCl3 / 6 h 2: 84 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating View Scheme
参考文献
Predvoditeleva, G. S.; Kartseva, T. V.; Oleshko, O. N.; Shvedov, V. I.; Syubaev, R. D.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 4 p. 275 - 278
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 4 p. 441 - 445
反应条件
sodium hydroxide in ethanol; water 4 h; Heating;
参考文献
Moser; Sallmann; Wiesenberg
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2358 - 2368
反应条件
sodium dithionite; water; potassium hydroxide 8.5 h; Reflux;
参考文献
COSMA S.P.A.; IBSA INSTITUT BIOCHIMIQUE S.A.; AVOGADRI, Alvaro; LUSSANA, Massimiliano; PIZZATTI, Enrica; BARETTI, Sergio
Patent: WO2010/69397 A1, 2010 ;
Location in patent: Page/Page column 8-9 ;
