(4S,5R)-3-苯甲酰基-2,2-二甲基-4-苯基氧氮杂环戊烷-5-甲酸合成路线 （共 13 条）
反应条件
lithium hydroxide; water in methanol Ambient temperature;
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1: With lithium hydroxide in tetrahydrofuran; water T=20°C; 0.583333 h; 2: With hydrogenchloride in water
参考文献
Bristol Myers Squibb Comp.
Patent: US6365750 B1, 2002 ;
Location in patent: Example 6 ;
反应条件
1: aq. PTSA / 80 °C 2: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: K2OsO2; (DHQ)2PHAL 2: aq. HCl / 2 h / Heating 3: HCl 4: NaHCO3 / ethyl acetate 5: aq. PTSA / 80 °C 6: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: HCl 2: NaHCO3 / ethyl acetate 3: aq. PTSA / 80 °C 4: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: NaHCO3 / ethyl acetate 2: aq. PTSA / 80 °C 3: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: NaHCO3 / ethyl acetate 2: aq. PTSA / 80 °C 3: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: aq. HCl / 2 h / Heating 2: HCl 3: NaHCO3 / ethyl acetate 4: aq. PTSA / 80 °C 5: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: 1.) methyl triflate, 4 Angstroem molecular sieves; 2.) NaBH4; 3.) CuO/CuCl2*2H2O / 1.) MeCN, r.t., 30 min; 2.) MeOH, r.t., 10 min; 3.) MeCN/H2O, 15 min, r.t. 2: KMnO4, potassium phosphate / 2-methyl-propan-2-ol; H2O / 0.25 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 2 p. 181 - 186
反应条件
1: 1.) HN3, Ph3P, DEAD; 2.) PPh3, H2O / 1.) benzene, r.t.; 2.) THF, 55 deg C 2: 90 percent / DMAP / CH2Cl2 / 0 °C 3: 96 percent / SnCl4 / CH2Cl2 / Heating 4: 84 percent / AgOCOCF3 / Ambient temperature 5: 89 percent / PPTS / toluene / 85 °C 6: 86 percent / LiOH, H2O / methanol / Ambient temperature View Scheme
参考文献
Chemistry Letters, , # 1 p. 3 - 4
