lithium diisopropyl amide T=-78°C; 1 h; regioselectivity, var. halogens in var. positions; Product distribution;

N,N,N',N',N'',N''-hexamethylphosphoric triamide; copper(l) iodide in N,N-dimethyl-formamide T=70°C;

1: n-butyllithium With zinc(II) chloride in tetrahydrofuran; hexane T=0°C; transmetallation; 0.25 h; 2: 2-iodophenyl triflate in tetrahydrofuran; hexane T=20°C; Metallation; alkylation; 1 h; 3: With hydrogenchloride in tetrahydrofuran; hexane Hydrolysis;

lithium diisopropyl amide T=-78°C; 1 h; regioselectivity, var. halogens in var. positions; Product distribution;

1: n-butyllithium With zinc(II) chloride in tetrahydrofuran; hexane T=0°C; transmetallation; 0.25 h; 2: tetrahydrofuran; 2-iodophenyl triflate in hexane T=-85 - 20°C; Metallation; alkylation; 2 h; 3: With iodine in tetrahydrofuran; hexane T=-85°C; Iodination; 0.25 h;

1: With lithium tri-n-butylzincate in tetrahydrofuran; hexane T=-85°C; Metallation; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran; hexane Hydrolysis;