N-(4-叠氮基苯甲酰基)-N-去苯甲酰基紫杉醇合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in ethyl acetate
0.0833333 h;
参考文献
Dasgupta; Park; Harriman; Georg; Himes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2976 - 2980
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 2.) THF, hexane, -78 deg C, 10 min
2: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, 35 deg C, 1 h
3: 92 percent / C5H5N*HF / pyridine / 1.) 0 deg C, 1 h, 2.) RT, 5 h
4: 94 percent / H2 / 10percent Pd/C / methanol / 5 h / 2585.7 Torr
5: 72 percent / aq. NaHCO3 / ethyl acetate / 0.08 h
View Scheme
参考文献
Dasgupta; Park; Harriman; Georg; Himes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2976 - 2980
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
1 h;
参考文献
Swindell, Charles S.; Heerding, Julia M.; Krauss, Nancy E.; Horwitz, Susan Band; Rao, Srinivasa; Ringel, Israel
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1446 - 1449
反应条件
1: SOCl2 / 5 h / Heating
2: 72 percent / aq. NaHCO3 / ethyl acetate / 0.08 h
View Scheme
参考文献
Dasgupta; Park; Harriman; Georg; Himes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2976 - 2980
反应条件
1: DMAP; Hunig's base / CH2Cl2
2: LiHMDS / tetrahydrofuran / -40 °C
3: HF; pyridine / acetonitrile
View Scheme
参考文献
Shu; Heys
Tetrahedron Letters, 2000 , vol. 41, # 47 p. 9015 - 9019
反应条件
1: DMAP; Hunig's base / CH2Cl2
2: LiHMDS / tetrahydrofuran / -40 °C
3: HF; pyridine / acetonitrile
View Scheme
参考文献
Shu; Heys
Tetrahedron Letters, 2000 , vol. 41, # 47 p. 9015 - 9019
反应条件
1: LiHMDS / tetrahydrofuran / -40 °C
2: HF; pyridine / acetonitrile
View Scheme
参考文献
Shu; Heys
Tetrahedron Letters, 2000 , vol. 41, # 47 p. 9015 - 9019
参考文献
BRYN MAWR COLLEGE
Patent: EP1260507 A1, 2002 ;
Location in patent: Page 8-9, 17 ;
参考文献
BRYN MAWR COLLEGE
Patent: EP1260507 A1, 2002 ;
Location in patent: Page 8-9 ;
