1-Boc-2-氰基哌啶合成路线 （共 10 条）
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane; acetonitrile T=-5°C; 0.25 h; 2: rac-N-(tert-butoxycarbonyl)piperidine-2-carboxamide With pyridine in dichloromethane; acetonitrile T=20°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/80386 A1, 2005 ;
Location in patent: Page/Page column 42-43 ;
WO 2005/080386 A1
反应条件
tetra-n-butylammonium tetrafluoroborate in acetonitrile T=20°C; Electrochemical reaction;
参考文献
Tajima, Toshiki; Nakajima, Atsushi
Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10496 - 10497
反应条件
methanesulfonic acid; tetraethylammonium tetrafluoroborate in dichloromethane; acetonitrile T=0°C; Electrochemical reaction;
参考文献
Libendi, Samuel Shikuku; Demizu, Yosuke; Onomura, Osamu
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 2 p. 351 - 356
反应条件
ammonium cerium(IV) nitrate in acetonitrile T=-45°C; 2 h;
参考文献
Narasaka, Koichi; Kohno, Yasushi
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 11 p. 3456 - 3463
反应条件
in acetonitrile T=20°C; Electrochemical reaction;
参考文献
Tajima, Toshiki; Nakajima, Atsushi
Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10496 - 10497
反应条件
benzophenone in acetonitrile T=20°C; 5 h; Inert atmosphereUV-irradiation; Reagent/catalystTimeConcentration;
参考文献
Hoshikawa, Tamaki; Yoshioka, Shun; Kamijo, Shin; Inoue, Masayuki
Synthesis (Germany), 2013 , vol. 45, # 7 art. no. SS-2012-Z0984-FA, p. 874 - 887
反应条件
in tetrahydrofuran 48 h;
参考文献
Wolckenhauer, Scott A.; Rychnovsky, Scott D.
Organic Letters, 2004 , vol. 6, # 16 p. 2745 - 2748
反应条件
zinc(II) chloride in dichloromethane
参考文献
Nagasaka, Tatsuo; Hayashi, Hideki; Hamaguchi, Fumiko
Heterocycles, 1988 , vol. 27, # 7 p. 1685 - 1696
反应条件
1.1: isopropyl chloroformate; triethylamine / CH2Cl2 / 0.5 h / -30 - -20 °C 1.2: 60 percent / aq. NH3 / CH2Cl2 / -30 - 20 °C 2.1: 89 percent / trifluoroacetic anhydride; triethylamine View Scheme
参考文献
Synthetic Communications, , vol. 37, # 21 p. 3793 - 3799
反应条件
1.1: LDA; dimethylpropyleneurea / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 90 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: 1,10-phenanthroline; n-BuLi; lithium 4,4'-di-tert-butylbiphenylide / tetrahydrofuran; hexane / 0.08 h / -78 °C
2.2: 79 percent / tetrahydrofuran; hexane / 15 h / -78 °C
View Scheme
参考文献
Wolckenhauer, Scott A.; Rychnovsky, Scott D.
Organic Letters, 2004 , vol. 6, # 16 p. 2745 - 2748
