3-乙基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 23 条）
反应条件
N-bromosuccinmide in acetonitrile T=0 - 20°C; 6 h;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: US2007/232619 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 1,3-dihydro-indol-2-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-25°C; 0.5 h; Nitrogen atmosphere;
2: ethyl iodide in tetrahydrofuran; hexane
T=-25 - 20°C;
参考文献
American Home Products Corporation; Ligand Pharmaceuticals, Inc.
Patent: US6355648 B1, 2002 ;
Location in patent: Page column 56-57 ;
US 6355648 B1
反应条件
palladium diacetate; hydrogen; tri-cyclo-hexyl-phosphine in dichloromethane
T=100°C; P=31028.9 Torr; 48 h;
参考文献
El Ali, Bassam; Okuro, Kazumi; Vasapollo, Giuseppe; Alper, Howard
Journal of the American Chemical Society, 1996 , vol. 118, # 18 p. 4264 - 4270
反应条件
hydrogen; nickel
T=150°C; P=11250.9 Torr; 25 h;
参考文献
Volk, Balazs; Simig, Gyula
European Journal of Organic Chemistry, 2003 , # 20 p. 3991 - 3996
反应条件
nickel
T=150°C; 5 h;
参考文献
Volk, Balazs; Mezei, Tibor; Simig, Gyula
Synthesis, 2002 , # 5 p. 595 - 597
反应条件
Pd(PCy3)2(H)(H2O)+BF4-; hydrogen; 1,4-di(diphenylphosphino)-butane in toluene
T=100°C; P=31028.9 Torr; 48 h; Yield given. Yields of byproduct given;
参考文献
El Ali, Bassam; Okuro, Kazumi; Vasapollo, Giuseppe; Alper, Howard
Journal of the American Chemical Society, 1996 , vol. 118, # 18 p. 4264 - 4270
反应条件
palladium diacetate; hydrogen; 1,4-di(diphenylphosphino)-butane in dichloromethane
T=100°C; P=31028.9 Torr; 48 h; Yield given. Yields of byproduct given;
参考文献
El Ali, Bassam; Okuro, Kazumi; Vasapollo, Giuseppe; Alper, Howard
Journal of the American Chemical Society, 1996 , vol. 118, # 18 p. 4264 - 4270
反应条件
sodium tetrahydroborate; acetic acid
T=75°C; 1 h;
参考文献
Smith, Francis X.; Williams, Brian D.; Gelsleichter, Eric; Podcasy, Judy A.; Sisko, John T.; Hrubowchak, David M.
Synthetic Communications, 2006 , vol. 36, # 6 p. 765 - 769
参考文献
Wenkert; Bringi
Journal of the American Chemical Society, 1958 , vol. 80, p. 5575
反应条件
palladium on activated charcoal; ethanol
Hydrogenation;
参考文献
Kondo et al.
Itsuu Kenkyusho Nempo, 1950 , # 1 p. 32,36; engl. Ref. S. 74, 78
Chem.Abstr., 1953 , p. 3857
