3-乙基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 23 条）
反应条件
1: 1,3-dihydro-indol-2-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: ethyl bromide in tetrahydrofuran; hexane
T=-78 - -20°C; Inert atmosphere;
参考文献
Trost, Barry M.; Zhang, Yong; Zhang, Ting
Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5115 - 5117
反应条件
1: boron trifluoride etherate / methanol; acetic acid / 30 h / Ambient temperature
2: 79 percent / Raney nickel / benzene / 4 h / Heating
3: 90 percent / Raney nickel / 72 h / Heating
View Scheme
参考文献
Wenkert, Ernest; Bringi, N. V.; Choulett, Harry E.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 5 p. 348 - 350
反应条件
air; dihydrogen peroxide; horseradish peroxidase in methanol; phosphate buffer
pH=7.0;
参考文献
Ling, Ke-Qing; Sayre, Lawrence M.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 10 p. 3543 - 3551
反应条件
nickel
24 h; Heating;
参考文献
Wenkert, Ernest; Bringi, N. V.; Choulett, Harry E.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 5 p. 348 - 350
反应条件
methyllithium; calcium carbonate
T=190 - 200°C;
参考文献
Brunner
Monatshefte fuer Chemie, 1897 , vol. 18, p. 533
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux
2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: toluene / 10 h / 110 °C
2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: boron trifluoride diethyl etherate / m-xylene
2: toluene / 10 h / 110 °C
3: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
反应条件
1: sodium sulfate; N,Ndimethylaniline
2: palladium/charcoal; ethanol / Hydrogenation
View Scheme
参考文献
Kondo et al.
Itsuu Kenkyusho Nempo, 1950 , # 1 p. 32,36; engl. Ref. S. 74, 78
Chem.Abstr., 1953 , p. 3857
参考文献
Wenkert et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 4899,4903
