3-[(4-氯苯基)氨基]-3-氧代丙酸乙酯合成路线 （共 15 条）
反应条件
1: Verseifung 2: beim Schmelzen View Scheme
参考文献
Chattaway; Mason
Journal of the Chemical Society, 1910 , vol. 97, p. 344
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1405852 A1, 2004 ;
Location in patent: Page 231 ;
EP 1405852 A1
反应条件
pyridine in dichloromethane
T=0 - 20°C;
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Patent: WO2008/70891 A1, 2008 ;
Location in patent: Page/Page column 38-39 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1405852 A1, 2004 ;
Location in patent: Page 231 ;
EP 1405852 A1
反应条件
in di-isopropyl ether; benzene
参考文献
Laboratoire L. Lafon
Patent: US4122186 A1, 1978 ;
反应条件
sodium chloride; sodium hydrogencarbonate; citric acid in N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: US2005/20645 A1, 2005 ;
反应条件
diisopropyl-carbodiimide in N,N-dimethyl-formamide
T=20°C;
参考文献
Adhikari, Raju; Jones, Dionne A.; Liepa, Andris J.; Nearn, Roland H.
Australian Journal of Chemistry, 2005 , vol. 58, # 12 p. 882 - 890
参考文献
Rhone-Poulenc Inc.
Patent: US5292937 A1, 1994 ;
参考文献
Rhone-Poulenc Nederland B.V.
Patent: US5123951 A1, 1992 ;
反应条件
hydrogenchloride in ethanol
参考文献
Effenberger,F. et al.
Chemische Berichte, 1966 , vol. 99, p. 3892 - 3902
