5-溴-1-甲基-3-硝基吡啶-2(1h)-酮合成路线 （共 4 条）
反应条件
1: 2-hydroxy-3-nitro-5-bromopyridine With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
US2009/82330 A1, ;
Page/Page column 39-40 ;
反应条件
1: 5-bromo-3-nitropyridin-2(1H)-one; N,N-dimethyl-formamide With potassium carbonate T=20°C; 0.25 h; Reflux; 2: methyl iodide T=20°C; 16 h;
参考文献
WO2012/31004 A1, ;
Page/Page column 110 ;
WO 2012/031004 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 2 p. 755 - 758
反应条件
1: With hydrogenchloride; water; iron in ethanol T=60°C; 2 h; 2: With water; potassium carbonate in ethanol pH=8;
参考文献
US2009/82330 A1, ;
Page/Page column 39-41 ;
