2-[(2S)-2-丁烷基]-4-{4-[4-(4-甲氧基苯基)-1-哌嗪基]苯基}-2,4-二氢-3H-1,2,4-三唑-3-酮合成路线 （共 5 条）
反应条件
18-crown-6 ether; potassium carbonate in dimethyl sulfoxide T=20°C;
参考文献
Shi, Wei; Nacev, Benjamin A.; Bhat, Shridhar; Liu, Jun O.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 4 p. 155 - 159
反应条件
tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=90°C; 17 h;
参考文献
Tanoury, Gerald J.; Senanayake, Chris H.; Hett, Robert; Kuhn, Amy M.; Kessler, Donald W.; Wald, Stephen A.
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6845 - 6848
反应条件
1: butan-1-ol / 0 °C 2: 49 percent / KOH / butan-1-ol / 3 h / Heating 3: 1.) KH, 18 crown-6 / 1.) DMF, 2.) DMF, 0 deg C 4: 65 percent / Pd2(dba)3, BINAP, t-BuONa / toluene / 17 h / 90 °C View Scheme
参考文献
Tanoury, Gerald J.; Senanayake, Chris H.; Hett, Robert; Kuhn, Amy M.; Kessler, Donald W.; Wald, Stephen A.
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6845 - 6848
反应条件
1: 1.) KH, 18 crown-6 / 1.) DMF, 2.) DMF, 0 deg C 2: 65 percent / Pd2(dba)3, BINAP, t-BuONa / toluene / 17 h / 90 °C View Scheme
参考文献
Tanoury, Gerald J.; Senanayake, Chris H.; Hett, Robert; Kuhn, Amy M.; Kessler, Donald W.; Wald, Stephen A.
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6845 - 6848
反应条件
1: 49 percent / KOH / butan-1-ol / 3 h / Heating 2: 1.) KH, 18 crown-6 / 1.) DMF, 2.) DMF, 0 deg C 3: 65 percent / Pd2(dba)3, BINAP, t-BuONa / toluene / 17 h / 90 °C View Scheme
参考文献
Tanoury, Gerald J.; Senanayake, Chris H.; Hett, Robert; Kuhn, Amy M.; Kessler, Donald W.; Wald, Stephen A.
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6845 - 6848
