2-[(8-氯-1-甲基-6-苯基-[1,2,4]三唑并[4,3-a][1,5]苯并二氮杂卓-5-基)硫基]-N,N-二甲基乙胺合成路线 （共 4 条）
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in chlorobenzene Ambient temperature;
参考文献
Grossi; Di Braccio; Roma; Ghia; Brambilla
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 577 - 584
反应条件
1: 78 percent / Lawesson's reagent / various solvent(s) / 0.5 h / 150 °C 2: 82 percent / benzyltriethylammonium chloride (TEBA), 48percent aq. KOH / chlorobenzene / Ambient temperature View Scheme
参考文献
Grossi; Di Braccio; Roma; Ghia; Brambilla
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 577 - 584
反应条件
1: 70 percent / TiCl4, anisole / toluene / 6 h / Heating 2: 80 percent / gl. AcOH / various solvent(s) / 2 h / 200 °C 3: 78 percent / Lawesson's reagent / various solvent(s) / 0.5 h / 150 °C 4: 82 percent / benzyltriethylammonium chloride (TEBA), 48percent aq. KOH / chlorobenzene / Ambient temperature View Scheme
参考文献
Grossi; Di Braccio; Roma; Ghia; Brambilla
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 577 - 584
反应条件
1: 80 percent / gl. AcOH / various solvent(s) / 2 h / 200 °C 2: 78 percent / Lawesson's reagent / various solvent(s) / 0.5 h / 150 °C 3: 82 percent / benzyltriethylammonium chloride (TEBA), 48percent aq. KOH / chlorobenzene / Ambient temperature View Scheme
参考文献
Grossi; Di Braccio; Roma; Ghia; Brambilla
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 577 - 584
