2-氨基-3,5-二氟苯硫醇(9ci)合成路线 (共 1 条)
反应条件
1: pyridine / 2 h / 120 °C 2: phosphorus pentasulfide / benzene / 3 h / Heating 3: NaH / toluene / 0.5 h / Heating 4: aq. NaOH / ethane-1,2-diol / 3 h / 125 °C View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152