N-甲基-3,4-二羟基安非他命盐酸盐合成路线 (共 4 条)
反应条件
NADPH; human liver microsomes in phosphate buffer T=37°C; pH=7.4; 0.0333333 h; Enzyme kinetics; Further Variations:Catalysts;
参考文献
Kreth, Klaus-Peter; Kovar, Karl-Artur; Schwab, Matthias; Zanger, Ulrich M.
Biochemical Pharmacology, 2000 , vol. 59, # 12 p. 1563 - 1571
参考文献
Borgman,R.J. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 427 - 430
参考文献
Alles; Icke
Patent: US2378889 , 1943 ;
反应条件
cytochrome P450 2D6 wild-type Enzyme kinetics;
参考文献
Keizers, Peter H. J.; De Graaf, Chris; De Kanter, Frans J. J.; Oostenbrink, Chris; Feenstra, K. Anton; Commandeur, Jan N. M.; Vermeulen, Nico P. E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 6117 - 6127