2-(2-丁基)乙酰乙酸乙酯合成路线 （共 17 条）
反应条件
1: (+/-)-ethyl 3-methyl-2-oxopentanoate With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: acetyl chloride in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/62370 A2, 2007 ;
Location in patent: Page/Page column 143 ;
反应条件
carbonic acid diethyl ester T=95 - 105°C;
参考文献
Wallingford; Thorpe; Homeyer
Journal of the American Chemical Society, 1942 , vol. 64, p. 581
参考文献
Clarke
Journal of the American Chemical Society, 1908 , vol. 30, p. 1147
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Locquin
Bulletin de la Societe Chimique de France, 1906 , vol. <3> 35, p. 964
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Bouveault; Locquin
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 141, p. 116
Bulletin de la Societe Chimique de France, 1906 , vol. <3> 35, p. 967
反应条件
sodium ethanolate in ethanol
参考文献
Makisumi,Y.
Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 789 - 796
反应条件
unter verschiedenen Bedingungen;
参考文献
Renfrow; Renfrow
Journal of the American Chemical Society, 1946 , vol. 68, p. 1802
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Kurts,A.L. et al.
Tetrahedron, 1971 , vol. 27, p. 4777 - 4785
参考文献
Rhoads,S.J. et al.
Tetrahedron Letters, 1963 , p. 669 - 672
反应条件
in dimethyl sulfoxide
参考文献
Suama,M. et al.
Bulletin of the Chemical Society of Japan, 1971 , vol. 44, # 7 p. 1999
反应条件
(i) K, EtOH, (ii) /BRN= 1718770/, HMPA; Multistep reaction;
参考文献
Le Noble,W.J.; Morris,H.F.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1969 - 1973
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 1730915/; Multistep reaction;
参考文献
Rouillier,P. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 689 - 697
