2-氨基-5-乙氧羰基-4-羟基嘧啶合成路线 （共 20 条）
反应条件
sodium ethanolate in ethanol T=20°C; 96 h;
参考文献
Bonger, Kimberly M.; van den Berg, Richard J.B.H.N.; Heitman, Laura H.; IJzerman, Ad P.; Oosterom, Julia; Timmers, Cornelis M.; Overkleeft, Herman S.; van der Marel, Gijsbert A.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4841 - 4856
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 93 percent / sodium / Ambient temperature
4: NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
