叔-丁基-7-氨基-3,4-二氢异喹啉-2(1H)-甲酸合成路线 （共 4 条）
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane T=-75 - -60°C; Inert atmosphere; 2: With iodine in tetrahydrofuran; pentane T=-75 - -63°C;
参考文献
F. HOFFMANN-LA ROCHE AG; BISSANTZ, Caterina; DEHMLOW, Henrietta; ERICKSON, Shawn David; KARNACHI, Prabha Saba; KIM, Kyungjin; MARTIN, Rainerm, E.; MATTEI, Patrizio; OBST SANDER, Ulrike; PIETRANICO-COLE, Sherrie Lynn; RICHTER, Hans; ULLMER, Christoph
Patent: WO2012/117000 A1, 2012 ;
Location in patent: Page/Page column 157; 158 ;
反应条件
iodine in diethyl ether; water
反应条件
1: 75 percent / NaHMDS / tetrahydrofuran 2: 1.) n-BuLi, TMEDA, 2.) I2 / 1.) THF, -78 deg C and -10 deg C, 1 h, 2.) THF, -78 deg C to 0 deg C, 2 h View Scheme
参考文献
Heterocycles, , vol. 51, # 4 p. 721 - 726
反应条件
1: 75 percent / NaHMDS / tetrahydrofuran 2: 1.) n-BuLi, TMEDA, 2.) I2 / 1.) THF, -78 deg C and -10 deg C, 1 h, 2.) THF, -78 deg C to 0 deg C, 2 h View Scheme
参考文献
Heterocycles, , vol. 51, # 4 p. 721 - 726
