3-溴甲基-2-环丙基-4-(4'-氟苯基)喹啉合成路线 （共 11 条）
反应条件
phosphorus tribromide in dichloromethane; toluene 3 h; Ambient temperature;
参考文献
Hiyama; Minami; Takahashi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 1 p. 364 - 372
反应条件
N-bromosuccinmide in tetrachloromethane; acetonitrile T=20°C; 96 h; UV-irradiation;
参考文献
LEK PHARMACEUTICALS D.D.; CASAR, Zdenko; STERK, Damjan; JUKIC, Marko
Patent: WO2012/13325 A1, 2012 ;
Location in patent: Page/Page column 65-66 ;
反应条件
1: toluene-4-sulfonic acid / toluene / 24 h / 105 °C / Sealed reactor 2: N-bromosuccinmide / tetrachloromethane; acetonitrile / 96 h / 20 °C / UV-irradiation View Scheme
反应条件
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 5 °C 2: phosphorus tribromide / dichloromethane / 3.17 h / 0 - 20 °C View Scheme
反应条件
1: dichloromethane / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C 3: (-)-10-CSA / acetonitrile; water / 4 h / 20 °C View Scheme
反应条件
1: water / tetrahydrofuran / 56 h / Reflux 2: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 56 h / 25 °C View Scheme
反应条件
water; sodium hydrogencarbonate in acetonitrile 64 h; Reflux;
参考文献
Fabris, Jan; Casar, Zdenko; Smilovic, Ivanagazi
Synthesis (Germany), 2012 , vol. 44, # 11 art. no. SS-2012-T0161-OP, p. 1700 - 1710
反应条件
in tetrahydrofuran 64 h; Inert atmosphereReflux;
参考文献
Fabris, Jan; Casar, Zdenko; Smilovic, Ivanagazi
Synthesis (Germany), 2012 , vol. 44, # 11 art. no. SS-2012-T0161-OP, p. 1700 - 1710
反应条件
in toluene 12 h; Heating;
参考文献
Hiyama; Minami; Takahashi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 1 p. 364 - 372
反应条件
1: 100 percent / toluene / 12 h / Heating 2: 1.) lithium 2,2,6,6-tetramethylpiperidine / 1.) THF, RT, 30 min, 2.) THF, 3 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 68, # 1 p. 364 - 372
