1: 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 h / 0 - 20 °C 2: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux 3: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr 4: PyAOP / dichloromethane / 3.75 h / 0 - 20 °C 5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

1: 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 h / 0 - 20 °C 2: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux 3: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr 4: PyAOP / dichloromethane / 3.75 h / 0 - 20 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: Boc-ON; Et₃N / dioxane<br />1.2: N-ethyl-N-(3-dimethylaminopropyl)carbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 0 &deg;C<br />2.1: CF₃CO₂H / CH₂Cl₂ <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: Boc-ON; Et₃N / dioxane<br />1.2: N-ethyl-N-(3-dimethylaminopropyl)carbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 0 &deg;C<br />2.1: CF₃CO₂H / CH₂Cl₂ <br /> <br /> &nbsp;