2-(2-环己烯)异吲哚啉-1,3-二酮合成路线 （共 16 条）
反应条件
in N,N-dimethyl-formamide 12 h; Heating;
参考文献
THE GOVERNMENT OF UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Patent: WO2005/28436 A2, 2005 ;
Location in patent: Page/Page column 57 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 0.25 h; Ambient temperature;
参考文献
Sammes, Peter G.; Thetford, Dean
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2275 - 2278
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; 1,3-bis-(diphenylphosphino)propane; sodium carbonate in toluene T=140°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Banerjee, Debasis; Junge, Kathrin; Beller, Matthias
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1630 - 1635
Angew. Chem., 2014 , vol. 126, # 6 p. 1656 - 1661,6
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=20°C;
参考文献
Wei, Ying; Liang, Fushun; Zhang, Xintong
Organic Letters, 2013 , vol. 15, # 20 p. 5186 - 5189
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Mitsunobu reaction;
参考文献
Csatayova, Kristina; Davies, Stephen G.; Lee, James A.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Thomson, James E.
Tetrahedron, 2010 , vol. 66, # 43 p. 8420 - 8440
反应条件
in acetonitrile T=60 - 70°C; Yield given;
参考文献
Barrett, Anthony G. M.; Braddock, D. Christopher; James, Rachel A.; Procopiou, Panayiotis A.
Chemical Communications, 1997 , # 5 p. 433 - 434
反应条件
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran View Scheme
参考文献
Csatayova, Kristina; Davies, Stephen G.; Lee, James A.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Thomson, James E.
Tetrahedron, 2010 , vol. 66, # 43 p. 8420 - 8440
反应条件
copper(l) chloride; benzene
参考文献
Fono
Chemistry and Industry (London, United Kingdom), 1958 , p. 414
反应条件
N-(chloromethylene)-N-methylmethanaminium chloride 1.) MeCN, 2.) 65 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Barrett, Anthony G. M.; Braddock, D. Christopher; James, Rachel A.; Koike, Nobuyuki; Procopiou, Panayiotis A.
Journal of Organic Chemistry, 1998 , vol. 63, # 18 p. 6273 - 6280
反应条件
1: 99 percent / sodium borohydride / propan-2-ol; H2O / 1 h / 0 deg C -> room temperature 2: 87 percent / NBS / CHCl3 / 1 h / Ambient temperature 3: 60 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 4: 73 percent / 6 M HCl / methanol / 0.5 h / Heating View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2275 - 2278
