2-(2-环己烯)异吲哚啉-1,3-二酮合成路线 （共 16 条）
反应条件
1: 99 percent / sodium borohydride / propan-2-ol; H2O / 1 h / 0 deg C -> room temperature 2: 87 percent / NBS / CHCl3 / 1 h / Ambient temperature 3: 60 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 4: 73 percent / 6 M HCl / methanol / 0.5 h / Heating View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2275 - 2278
反应条件
1: 99 percent / sodium borohydride / propan-2-ol; H2O / 1 h / 0 deg C -> room temperature 2: 87 percent / NBS / CHCl3 / 1 h / Ambient temperature 3: 60 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 4: 73 percent / 6 M HCl / methanol / 0.5 h / Heating View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2275 - 2278
反应条件
1: 96 percent / NBS / CHCl3; ethanol / 8 h / Ambient temperature 2: 98 percent / 2 M HCl / methanol / 0.5 h / Ambient temperature 3: 80 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 4: 1.) hydrazine hydrate, 2.) conc. HCl / 1.) 95 percent ethanol, reflux, 2 h, 2.) room temperature View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 655 - 661
反应条件
1: 96 percent / NBS / CHCl3; ethanol / 8 h / Ambient temperature 2: 98 percent / 2 M HCl / methanol / 0.5 h / Ambient temperature 3: 80 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 4: 1.) hydrazine hydrate, 2.) conc. HCl / 1.) 95 percent ethanol, reflux, 2 h, 2.) room temperature View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 655 - 661
反应条件
hydrazine hydrate in ethanol
Heating;
参考文献
Turk,S.D. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2846 - 2853
反应条件
1: 99 percent / sodium borohydride / propan-2-ol; H2O / 1 h / 0 deg C -> room temperature
2: 87 percent / NBS / CHCl3 / 1 h / Ambient temperature
3: 60 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating
4: 73 percent / 6 M HCl / methanol / 0.5 h / Heating
View Scheme
参考文献
Sammes, Peter G.; Thetford, Dean
Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2275 - 2278
