(2-甲氧基苯基)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 12 条）
反应条件
in tetrahydrofuran Heating;
参考文献
Nakamura, Itaru; Yamagishi, Uichiro; Song, Dschun; Konta, Sayaka; Yamamoto, Yoshinori
Angewandte Chemie - International Edition, 2007 , vol. 46, # 13 p. 2284 - 2287
反应条件
1: 2-chloro-anisole With Pd[P(o-tol)3]2; CyPF-t-Bu; ammonia; sodium t-butanolate in 1,4-dioxane T=100°C; 12 h; Inert atmosphere; 2: di-tert-butyl dicarbonate With triethylamine in 1,4-dioxane T=80°C; 12 h; Inert atmosphere;
参考文献
Vo, Giang D.; Hartwig, John F.
Journal of the American Chemical Society, 2009 , vol. 131, # 31 p. 11049 - 11061
反应条件
CyGemPhos; water; palladium diacetate; caesium carbonate in 1,4-dioxane T=125°C; Buchwald-Hartwig coupling; 24 h;
参考文献
Falk, Florian C.; Froehlich, Roland; Paradies, Jan
Chemical Communications, 2011 , vol. 47, # 39 p. 11095 - 11097
反应条件
cBRIDP; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate in water T=50°C; 24 h; Inert atmosphereGreen chemistry;
参考文献
Isley, Nicholas A.; Dobarco, Sebastian; Lipshutz, Bruce H.
Green Chemistry, 2014 , vol. 16, # 3 p. 1480 - 1488
反应条件
n-butyllithium; dimethylsulfide; copper(I) bromide 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 to -60 deg C, 1 h, 3.) THF, hexane, -78 to 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Greck, Christine; Bischoff, Laurent; Girard, Anne; Hajicek, Josef; Genet, Jean-Pierre
Bulletin de la Societe Chimique de France, 1994 , vol. 131, # 4 p. 429 - 433
反应条件
1: 1.) t-BuLi, 2.) I2 / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C -> rt, overnight 2: 87 percent / CuI, Pd(PPh3)2Cl2 / triethylamine / 24 h / Ambient temperature 3: 70 percent / t-BuOK / 2-methyl-propan-2-ol / 3 h / Heating View Scheme
参考文献
Kondo, Yoshinori; Kojima, Satoshi; Sakamoto, Takao
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6507 - 6511
反应条件
1.1: t-BuLi / diethyl ether; pentane / 22 h / -25 °C 1.2: 61 percent / ICH2CH2Cl / diethyl ether; pentane / 16 h / 20 °C 2.1: BBr3 / CH2Cl2 / 16 h / -78 - 20 °C View Scheme
参考文献
Dumez, Estelle; Snaith, John S.; Jackson, Richard F. W.; McElroy, Andrew B.; Overington, John; Wythes, Martin J.; Withka, Jane M.; McLellan, Thomas J.
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4882 - 4892
反应条件
1: With tert.-butyl lithium in diethyl ether; pentane T=-25°C; 22 h; 2: With 1-chloro-2-iodo-ethane in diethyl ether; pentane T=20°C; 16 h; Further stages.;
参考文献
Dumez, Estelle; Snaith, John S.; Jackson, Richard F. W.; McElroy, Andrew B.; Overington, John; Wythes, Martin J.; Withka, Jane M.; McLellan, Thomas J.
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4882 - 4892
反应条件
1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere; Reflux 2.1: acetyl chloride / methanol / 2 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Brucelle, Francois; Renaud, Philippe
Organic Letters, 2012 , vol. 14, # 12 p. 3048 - 3051
反应条件
1.1: t-BuLi / diethyl ether; pentane / 3 h / -20 °C 1.2: 47 percent / iodine / diethyl ether; pentane / -90 - 20 °C 2.1: CF3COOH / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Jia, Yanxing; Zhu, Jieping
Synlett, 2005 , # 16 art. no. G22605ST, p. 2469 - 2472
