1: TFA / 1 h / -6 °C 2: NaIO4 / methanol; H2O / Ambient temperature 3: 0.5 h / 130 °C / 20 Torr View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '113915', constants.ctx, '0')">N-chloro-succinimide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098295', constants.ctx, '0')">tetrachloromethane</a> <br />14&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: pyridine / 72 h / Ambient temperature<br />2: KOH / methanol / 1.) room temperature, 14 h, 2.) reflux, 1 h<br />3: NCS / CCl₄ / 14 h / Ambient temperature<br /> <br /> &nbsp;