3-氯-2,4-二氟苯甲酸合成路线 （共 13 条）
反应条件
1: 3-Chloro-2,4-difluoro-bromobenzene With n-butyllithium in diethyl ether T=-78 - -70°C; 0.25 h; 2: carbon dioxide T=-70°C;
参考文献
US6348624 B1, ;
Page column 10 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Rhone-Poulenc Agrochimie
Patent: US5945382 A1, 1999 ;
反应条件
hydrogenchloride; n-butyllithium; CO2 in water
反应条件
1: 1-chloro-2,6-difluorobenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane
参考文献
Heiss, Christophe; Rausis, Thierry; Schlosser, Manfred
Synthesis, 2005 , # 4 art. no. T11504SS, p. 617 - 621
反应条件
hydrogenchloride; n-butyllithium in water
反应条件
N,N,N',N,-tetramethylethylenediamine; 1,2,2-trichloro-1,1,2-trichloro-ethane; sec.-butyllithium in tetrahydrofuran 1.) -90 deg C, 30 min, 2.) -78 deg C;
参考文献
Bennetau, Bernard; Mortier, Jacques; Moyroud, Joel; Guesnet, Jean-Luc
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 10 p. 1265 - 1272
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 0.75 h / -75 °C 1.2: 74 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 90 percent / tetrahydrofuran; hexane View Scheme
参考文献
Synthesis, , # 4 art. no. T11504SS, p. 617 - 621
反应条件
1: 88 percent / 1.6 M n-BuLi / tetrahydrofuran; hexane / -78 deg C, 1 h; -78 to 5 deg C 2: n-BuLi / tetrahydrofuran; hexane / -78 deg C, 30 min; -78 to 5 deg C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 133, # 2 p. 133 - 141
反应条件
n-butyllithium in tetrahydrofuran; hexane -78 deg C, 30 min; -78 to 5 deg C;
参考文献
Bulletin de la Societe Chimique de France, , vol. 133, # 2 p. 133 - 141
反应条件
in N-methyl-acetamide; toluene
参考文献
Bayer Aktiengesellschaft
Patent: US5457104 A1, 1995 ;
