5-氯-2-甲基-3-硝基苯甲酸合成路线 （共 2 条）
反应条件
1: With sulfuric acid T=-10°C; 0.166667 h; 2: With nitric acid T=-10°C; 0.5 h; Product distribution / selectivity;
参考文献
EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun
Patent: WO2012/142513 A1, 2012 ;
Location in patent: Page/Page column 264 ;
WO 2012/142513 A1
反应条件
1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C 2: water; ammonium chloride; iron / ethanol / 1 h / 80 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar
Patent: WO2013/173441 A2, 2013 ;
