1-[3-溴-5-(三氟甲基)苯基]乙酮合成路线 （共 4 条）
反应条件
1: in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; water
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 56 ;
WO 2012/139775 A1
反应条件
1: 3-bromo-5-(trifluoromethyl)-phenylamine With hydrogenchloride; sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: acetaldehyde oxime With copper(II) sulfate in water T=20°C; 4 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 76 ;
US 20070249607 A1
反应条件
1: 1,3-dibromo-5-(trifluoromethyl)benzene With n-butyllithium in hexane; di-isopropyl ether T=-78°C; 0.5 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in hexane; di-isopropyl ether T=20°C; 0.5 h; Inert atmosphere;
参考文献
SAINT LOUIS UNIVERSITY; RUMINSKI, Peter; GRIGGS, David
Patent: WO2014/15054 A1, 2014 ;
Location in patent: Page/Page column 196 ;
反应条件
1: triethylamine; HATU / dichloromethane / 20 °C 2: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
WO 2012/139775 A1
