4-氯-8-甲氧基-2-甲基-喹唑啉合成路线 （共 3 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=60°C; 2 h;
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
1: 1.) DMAP, Et3N, 2.) (NH4)2CO3 / 1.) DMF, 90 deg C, 3 h, 2.) DMF, 90 deg C, 1 h 2: 64.7 percent / POCl3, PhNMe2 / 2 h / 60 °C View Scheme
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethyl acetate 3 h; Ambient temperature;
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
