1-[(4-氯苯基)甲基]-3-[(1,1-二甲基乙基)硫基]-5-甲氧基-ALPHA,ALPHA-二甲基-1H-吲哚-2-丙酸乙酯合成路线 （共 4 条）
反应条件
sodium acetate; acetic acid in toluene T=20°C; Fischer Indole Synthesis; 120 h;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: WO2008/67566 A1, 2008 ;
Location in patent: Page/Page column 99 ;
反应条件
acetic acid in toluene 96 h; Ambient temperature;
参考文献
Kolasa, Teodozyj; Bhatia, Pramila; Brooks, Clint D. W.; Hulkower, Keren I.; Bouska, Jennifer B.; Harris, Richard R.; Bell, Randy L.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 507 - 514
反应条件
1: 76 percent / diisopropylamine, tetrabutylammonium bromide / CH2Cl2 / 48 h / Ambient temperature 2: 50 percent / acetic acid / toluene / 96 h / Ambient temperature View Scheme
参考文献
Kolasa, Teodozyj; Bhatia, Pramila; Brooks, Clint D. W.; Hulkower, Keren I.; Bouska, Jennifer B.; Harris, Richard R.; Bell, Randy L.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 507 - 514
反应条件
1: 76 percent / diisopropylamine, tetrabutylammonium bromide / CH2Cl2 / 48 h / Ambient temperature 2: 50 percent / acetic acid / toluene / 96 h / Ambient temperature View Scheme
参考文献
Kolasa, Teodozyj; Bhatia, Pramila; Brooks, Clint D. W.; Hulkower, Keren I.; Bouska, Jennifer B.; Harris, Richard R.; Bell, Randy L.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 507 - 514
