5-(二甲氨基)甲基-2-呋喃甲醇合成路线 （共 16 条）
参考文献
Smith Kline and French Laboratories Limited
Patent: US4347191 A1, 1982 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=0°C; 1.5 h; 2: With sodium hydroxide; water in tetrahydrofuran 0.25 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/108957 A2, 2008 ;
Location in patent: Page/Page column 76 ;
反应条件
sulfuric acid; hydrogen; G-69B in anhydrous ethylene glycol dimethyl ether T=180°C; P=41372.9 Torr; 3 h; Product distribution / selectivity;
参考文献
ARCHER DANIELS MIDLAND COMPANY; HOWARD, Stephen J.; SANBORN, Alexandra J.
Patent: WO2012/82665 A1, 2012 ;
Location in patent: Page/Page column 11 ;
反应条件
formaldehyd; ethanol
参考文献
American Home Products Corporation
Patent: US4622402 A1, 1986 ;
反应条件
acetic acid T=100°C; 3 h;
参考文献
Manfredini, S.; Guarneri, M.; Simoni, D.; Grana, E.; Boselli, C.; et al.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 2 p. 153 - 162
反应条件
in ethanol 10 h; Heating;
参考文献
Navarro; Almeida; Anaya; Moran; Grande; Caballero; Palacios; Montero; San Roman
Pharmazie, 1995 , vol. 50, # 1 p. 12 - 15
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Mndshojan; Ogandshanjan
Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1959 , vol. 12, p. 291,294
Chem.Abstr., 1960 , p. 7674
反应条件
water T=65°C; pH 4.01; var. pHs and temp., also in solid-state;
参考文献
Teraoka; Otsuka; Matsuda
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 6 p. 601 - 604
反应条件
citric acid in water 6 h; Heating;
参考文献
Haywood, Phillip A.; Martin-Smith, Michael; Cholerton, Trevor J.; Evans, Michael B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 951 - 954
反应条件
hydrogenchloride; hydroquinone T=0°C; 20 h;
参考文献
Navarro; Almeida; Anaya; Moran; Grande; Caballero; Palacios; Montero; San Roman
Pharmazie, 1995 , vol. 50, # 1 p. 12 - 15
