4-乙酰氧基-6,7-二氟-2-乙硫基喹啉-3-羧酸乙酯合成路线 （共 8 条）
反应条件
triethylamine in chloroform T=0°C; 1 h;
参考文献
Matsuoka; Segawa; Makita; Ohmachi; Kashima; Nakamura K.-; Hattori; Kitano; Kise
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 92 percent / m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 67 percent / 48 h / 70 °C 3: 79 percent / xylene / 3 h / Heating 4: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 1.) K2CO3 / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, 3 h 2: 53 percent / NH3 / ethanol / 18 h / 80 °C 3: 58 percent / KHCO3 / dimethylformamide / 24 h / 80 °C 4: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 1.) NaH 2: 92 percent / m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 67 percent / 48 h / 70 °C 4: 79 percent / xylene / 3 h / Heating 5: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 67 percent / 48 h / 70 °C 2: 79 percent / xylene / 3 h / Heating 3: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 79 percent / xylene / 3 h / Heating 2: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 53 percent / NH3 / ethanol / 18 h / 80 °C 2: 58 percent / KHCO3 / dimethylformamide / 24 h / 80 °C 3: 93 percent / Et3N / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 2: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Matsuoka; Segawa; Makita; Ohmachi; Kashima; Nakamura K.-; Hattori; Kitano; Kise
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1773 - 1779
