1-氧代-2-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯合成路线 （共 11 条）
反应条件
1: With oxygen; ozone in methanol; dichloromethane T=-78°C; 1.75 h; 2: With sodium tetrahydroborate in methanol; dichloromethane T=-78 - 20°C; 17 h; 3: in acetone T=20°C; 0.166667 h;
参考文献
Pineiro, Jose Luis Castro; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; Yang, Lihu
Patent: US2003/225059 A1, 2003 ;
Location in patent: Page 27 ;
反应条件
1: With oxygen; ozone in methanol; dichloromethane T=-78°C; 1.58333 h; 2: With sodium tetrahydroborate in methanol; dichloromethane T=-78 - 20°C; 17 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 30 ;
反应条件
toluene-4-sulfonic acid in toluene 3 h; Heating;
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1.1: KHMDS / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / 1 h / -78 °C 2.1: O3 / methanol; CH2Cl2 / -78 °C 2.2: NaBH4 / 3 h / -78 - 20 °C 3.1: p-TsOH / toluene / 3 h / Heating View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1: 94 percent / CHCl3 / 8 h 2: 1.) (i-Pr)2NLi / 1.) THF, -70 deg C, 1 h, 2.) -20 deg C, 1 h; r.t., overnight View Scheme
参考文献
Cignarella; Villa; Barlocco
Farmaco, 1993 , vol. 48, # 10 p. 1439 - 1445
反应条件
1: 94 percent / CHCl3 / 8 h 2: 1.) (i-Pr)2NLi / 1.) THF, -70 deg C, 1 h, 2.) -20 deg C, 1 h; r.t., overnight View Scheme
参考文献
Cignarella; Villa; Barlocco
Farmaco, 1993 , vol. 48, # 10 p. 1439 - 1445
反应条件
lithium diisopropyl amide 1.) THF, -70 deg C, 1 h, 2.) -20 deg C, 1 h; r.t., overnight; Yield given. Multistep reaction;
参考文献
Cignarella; Villa; Barlocco
Farmaco, 1993 , vol. 48, # 10 p. 1439 - 1445
反应条件
methanol; acetyl chloride T=0 - 20°C; 16 h;
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1: With diisobutylaluminium hydride in dichloromethane T=-78 - 0°C; 5 h; 2: With water in dichloromethane T=0 - 20°C;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 30 ;
反应条件
1: DIBAL-H / CH2Cl2 / 5 h / -78 - 0 °C 2: PPh3; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C 3: AcCl; MeOH / 16 h / 0 - 20 °C View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
