反应条件
1: 2,2,2-trifluoroethyl mercaptan With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0°C; 0.45 h; Inert atmosphere;
2: bromoacetic acid methyl ester in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C;
参考文献
PHARMINOX LIMITED; HUMMERSONE, Marc, Geoffery; COUSIN, David
Patent: WO2012/85501 A1, 2012 ;
Location in patent: Page/Page column 86 ;
