(6-甲氧基-3-吡啶基)乙腈合成路线 （共 8 条）
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With sodium hydride in ethylene glycol dimethyl ether T=20°C; 0.25 h; 2: 2-methoxy-5-bromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=90°C; 6 h;
参考文献
Eisai Co., Ltd.
Patent: EP1439175 A1, 2004 ;
Location in patent: Page 44 ;
反应条件
1: 6-methoxy-3-hydroxymethyl pyridine With thionyl chloride in chloroform 2 h; Heating / reflux; 2: potassium cyanide in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
NOVO NORDISK A/S
Patent: WO2004/111031 A1, 2004 ;
Location in patent: Page 48 ;
WO 2004/111031 A1
反应条件
in dimethyl sulfoxide T=20°C; 18 h;
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 23 ;
US 20110224225 A1
反应条件
in acetonitrile 48 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
WO 2007/075567 A1
反应条件
in ethanol; water Reflux;
参考文献
Slowinski, Franck; Ben Ayad, Omar; Vache, Julien; Saady, Mourad; Leclerc, Odile; Lochead, Alistair
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8336 - 8346
反应条件
1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C 2: dimethyl sulfoxide / 18 h / 20 °C View Scheme
参考文献
Slowinski, Franck; Ben Ayad, Omar; Vache, Julien; Saady, Mourad; Leclerc, Odile; Lochead, Alistair
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8336 - 8346
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / -10 - 20 °C 2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C 3: dimethyl sulfoxide / 18 h / 20 °C View Scheme
参考文献
Slowinski, Franck; Ben Ayad, Omar; Vache, Julien; Saady, Mourad; Leclerc, Odile; Lochead, Alistair
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8336 - 8346
反应条件
1: With potassium hydroxide; ethanol; water 20 h; Heating / reflux; 2: With hydrogenchloride in water pH=5;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 93 ;
WO 2007/075567 A1
