1: With [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-20°C; 0.5 h; 2: With trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=2 - 3°C; 8 h; 3: With sodium hydrogencarbonate in dichloromethane; water

1: 96 percent / Rh2(OAc)4 / CHCl3 / Heating 2: 1) LiBEt3H, 2) 30percent H2O2 / 1) THF, -78 deg C, 2 h, 2) THF, MeOH, 20 deg C, 2 h View Scheme

1: acetic anhydride / Reflux 2: hydrogenchloride / 0 - 20 °C 3: triethylamine / dichloromethane / 0 - 20 °C 4: copper diacetate / N,N-dimethyl-formamide / 120 °C View Scheme

1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / Reflux 2: acetic anhydride / Reflux 3: hydrogenchloride / 0 - 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C 5: copper diacetate / N,N-dimethyl-formamide / 120 °C View Scheme

1: triethylamine / dichloromethane / 0 - 20 °C 2: copper diacetate / N,N-dimethyl-formamide / 120 °C View Scheme

dihydrogen peroxide; lithium triethylborohydride 1) THF, -78 deg C, 2 h, 2) THF, MeOH, 20 deg C, 2 h; Yield given. Multistep reaction;