(E)-3-[6-[(2,6-二氯苯基)巯基甲基]-3-(2-苯基乙氧基)吡啶-2-基]丙-2-烯酸合成路线 （共 7 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol 18 h; Ambient temperature;
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: 85 percent / toluene / 0.5 h / 50 °C 2: 53 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C 3: MCPBA / CH2Cl2 / 18 h / Ambient temperature 4: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 5: SOCl2 / toluene / 1 h 6: 87 percent / DBU / acetonitrile / 1 h / 50 °C 7: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: 53 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C 2: MCPBA / CH2Cl2 / 18 h / Ambient temperature 3: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 4: SOCl2 / toluene / 1 h 5: 87 percent / DBU / acetonitrile / 1 h / 50 °C 6: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: 53 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C 2: MCPBA / CH2Cl2 / 18 h / Ambient temperature 3: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 4: SOCl2 / toluene / 1 h 5: 87 percent / DBU / acetonitrile / 1 h / 50 °C 6: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: MCPBA / CH2Cl2 / 18 h / Ambient temperature 2: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 3: SOCl2 / toluene / 1 h 4: 87 percent / DBU / acetonitrile / 1 h / 50 °C 5: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: SOCl2 / toluene / 1 h 2: 87 percent / DBU / acetonitrile / 1 h / 50 °C 3: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
1: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 2: SOCl2 / toluene / 1 h 3: 87 percent / DBU / acetonitrile / 1 h / 50 °C 4: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
