NU 7026; 2-(4-吗啉基)-4H-萘并[1,2-b]吡喃-4-酮合成路线 （共 4 条）
反应条件
trifluoromethylsulfonic anhydride in dichloromethane T=0°C; 20 h;
参考文献
Griffin, Roger J.; Fontana, Gabriele; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Leahy, Justin J. J.; Martin, Niall; Richardson, Caroline; Rigoreau, Laurent; Stockley, Martin; Smith, Graeme C. M.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 569 - 585
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C 1.2: 78 percent / tetrahydrofuran; hexane / 16 h / 25 °C 2.1: 63 percent / triflic anhydride / CH2Cl2 / 20 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 569 - 585
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C 1.2: 78 percent / tetrahydrofuran; hexane / 16 h / 25 °C 2.1: 63 percent / triflic anhydride / CH2Cl2 / 20 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 569 - 585
反应条件
trichlorophosphate 1.) chlorobenzene, r.t., 30 min, 2.) chlorobenzene, 130 deg C, 4 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Farmaco, , vol. 53, # 7 p. 494 - 503
