1-甲基-3-三氟甲基-1H-吡唑合成路线 （共 13 条）
反应条件
in methanol 4 h; Heating;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
in methanol T=55°C; 20 h; Cooling with ice; Overall yield = 63 percent; Overall yield = 153 g;
参考文献
SOLVAY SA; BRAUN, Max Josef; FISCHER, Reiner
Patent: WO2013/167586 A1, 2013 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4898 - 4906
反应条件
in ethanol 2 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 39, # 5 p. 1025 - 1027
反应条件
in dichloromethane 2 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1087 - 1089
反应条件
bromine; iron T=100°C; 4 h;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; hexane pH=6;
参考文献
WO2005/12254 A1, ;
Page/Page column 135-136 ;
WO 2005/012254 A1
反应条件
1: 1-methyl-3-trifluoromethylpyrazol With n-butyllithium in tetrahydrofuran; hexanes; hexane T=-78°C; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexanes T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water T=20°C; 1.5 h;
参考文献
WO2012/7868 A2, ;
Page/Page column 75 ;
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 2 h; 2: With carbon dioxide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C; 2 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2007/43677 A1, 2007 ;
Location in patent: Page/Page column 486-487 ;
反应条件
1: 1-methyl-3-trifluoromethylpyrazol With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
