4-[4-氯-1-丁酰基]-A,A-二甲基苯乙酸甲酯合成路线 （共 30 条）
反应条件
hydrogenchloride in dichloromethane
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6242606 B1, 2001 ;
反应条件
potassium carbonate in acetonitrile T=40°C; 0.75 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 79 ;
反应条件
ZnF2; palladium(II) 2,4-pentanedionate; tri-tert-butyl phosphine in DMF (N,N-dimethyl-formamide) T=80°C; Product distribution / selectivity;
参考文献
AMR Technology, Inc.
Patent: US2006/63808 A1, 2006 ;
Location in patent: Page/Page column 9; 14 ;
反应条件
hydrogenchloride T=-10 - 20°C;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 78 ;
反应条件
hydrogenchloride; methanol T=40 - 45°C; 7 h;
参考文献
Jubilant Organosys Limited
Patent: EP2289867 A2, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride in methanol; hexane
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6242606 B1, 2001 ;
反应条件
aluminium trichloride in dichloromethane T=-15 - 45°C; 3 h;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Page column 51 ;
反应条件
hydrogenchloride 0.7 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 79 ;
反应条件
1: 2-Methyl-2-phenylpropionate, methyl ester With AlCl3, aluminium chloride in dichloromethane T=-10 - 0°C; 0.75 h; 2: γ-chlorobutyryl chloride With AlCl3, aluminium chloride in dichloromethane T=-10 - 0°C; Friedel Crafts Acylation; 24 h;
参考文献
WO2005/19175 A1, ;
Page/Page column 24 ;
反应条件
hydrogenchloride; water in toluene T=40°C; 12 h;
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
Location in patent: Paragraph 0121 ;
